Jr, North,D. Jr, Ross,C. Jr Agricultural herbicide use and risk of lymphoma and soft-tissue sarcoma. Epidemiology , 1 , — Health , 51 , — An expanded and updated international cohort study. Lancet , , — Jr Induction of cytochrome PA1. Acta Endrocrinol. Carcinogenesis , 19 , 1 — Cancer Res.
Natl Acad. USA , 94 , — Carcinogenesis , 16 , — Science , , — Carcinogenesis , 19 , — Steroid Biochem. USA , 93 , — I: Evidence of its haemoprotein nature. Vanden Heuvel,J. Biotechniques , 14 , — Cancer Epidemiol. Biomarkers Prev. Endocrinology , , — In Puga,A. Drug Metab. Jr, Denison,M. Jr Inducible, receptor-dependent protein—DNA interactions at a dioxin-responsive transcriptional enhancer.
USA , 85 , — Jr Protein-DNA interactions at a dioxin-responsive enhancer. Mutational analysis of the DNA-binding site for the liganded Ah receptor. Cancer , 69 , — Natl Cancer Inst. Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account. Sign In. Advanced Search.
Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Volume Article Contents Introduction. Materials and methods. Badawi , Alaa F.
Oxford Academic. Google Scholar. Ercole L. Eleanor G. Revision received:. Cite Cite Alaa F. Select Format Select format. Permissions Icon Permissions. Table I. Elimination does not follow first-order kinetics; compounds are released slowly from body stores over days to several months or years. Toxic dose. The acute toxic doses of these compounds are highly variable, and reports of acute human poisonings are limited.
Table II—21 ranks the relative toxicity of several common compounds. Ingestion of as little as 1 g of lindane can produce seizures in a child, and 10—30 g is considered lethal in an adult. The estimated adult lethal oral doses of aldrin and chlordane are 3—7 g each; that of dieldrin, 2—5 g. A year-old man died after ingesting 12 g of endrin.
A year-old man survived a g endosulfan ingestion but was left with a chronic seizure disorder. Skin absorption is a significant route of exposure, especially with aldrin, dieldrin, and endrin. Extensive or repeated as little as two applications on two successive days whole-body application of lindane to infants has resulted in seizures and death. Clinical presentation. Shortly after acute ingestion, nausea and vomiting occur, followed by paresthesias of the tongue, lips, and face; confusion; tremor; obtundation; coma; seizures; and respiratory depression.
Because chlorinated hydrocarbons are highly lipid-soluble, the duration of toxicity may be prolonged. Recurrent or delayed-onset seizures have been reported. Diagnosis is based on the history of exposure and clinical presentation. Specific levels. Chlorinated hydrocarbons can be measured in the serum, but levels are not routinely available. Your MyAccess profile is currently affiliated with '[InstitutionA]' and is in the process of switching affiliations to '[InstitutionB]'.
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Please make sure javascript is enabled in your browser. Chlorinated hydrocarbon CHC is a generic term given to compounds containing chlorine, carbon and hydrogen. The term can be used to describe organochlorine pesticides such as lindane and DDT, industrial chemicals such as polychlorinated biphenyls PCB , and chlorine waste products such as dioxins and furans.
These compounds are persistent in the environment and most bioaccumulates in the food chain. The human and environmental health risks of chlorinated hydrocarbons depend on the compound in question. As a general statement, exposure to chlorinated hydrocarbon has been associated with suppression of the immune system and cancer.
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